For more information regarding the Ulster Internship at the Riley Heart Research Center, please contact:
Robust and exciting opportunities exist for clinical Cardiology fellows in either pediatric or adult cardiology fellowships to participate in basic and translational research in well-established, NIH-funded laboratories. Six principal investigators within the Riley Heart Research Center operate established basic and translational laboratories investigating a variety of scientifically and clinically important questions. All of these laboratories have a common theme of collaboration, and a focus on events underlying congenital heart disease and/or repair of sick or injured heart tissue. Cardiology fellows are both welcomed and encouraged to talk with us about engaging in basic research during the research portion of their fellowship. They will have full access to our laboratories, mentorship, and group and training activities.
Six laboratories provide a wide range of molecular biology, protein chemistry, and transgenic animal analysis. These labs are as follows:
1. Dr. Loren J. Field, Ph.D. Research in this lab focuses on how to regenerate new heart tissue to replace damaged or dying cardiomyocytes. This laboratory uses a wide variety of transgenic and molecular biology techniques to understand basic events controlling the growth of new heart tissue.
2. Dr. Anthony Firulli, Ph.D. This laboratory is interested in the signaling pathways and regulation of the genes that lead to formation of the heart. Specifically, how is the heart divided into the right and left sides, and how can this process be controlled to cause normal formation of the heart or abnormal, congenital heart defects. Transgenic animals, molecular biology, and histology techniques are extensively used in this laboratory.
3. Dr. Lei Wei, Ph.D. This laboratory is interested in how heart tissue dies and responds to stress. In particular, a wide variety of molecular and transgenic techniques are used to understand how cardiomyocytes undergo apoptosis, and how this process can be altered to improve outcome in the setting of cardiomyopathies and artificial heart support, such as left ventricular assist devices.
4. Dr. Weinian Shou, Ph.D. This laboratory is interested in the embryology of the heart and developmental programs that are responsible for the heart's formation, and the later development of arrhythmias in the heart. Again, a wide variety of imaging technology, molecular biology, and transgenic animals are used extensively in this lab to understand how the heart forms.
5. Dr. R. Mark Payne, M.D. This laboratory is interested in the role of mitochondrial biology in cardiac function. Specifically, this laboratory uses a wide variety of molecular biology, protein chemistry, and transgenic animals to develop therapeutic interventions for heart disease in children and adults that involve correction of defects in mitochondrial function.
6. Dr. Michael Rubart, M.D. This laboratory is interested in the role of calcium in heart function and how calcium signaling is regulated in the heart. A particular interest is the innervation of the heart and how this may contribute to arrhythmias in cardiomyopathies and infarction. A wide variety of molecular biology, electrophysiology, innovative imaging technology, and transgenic animals are used in this laboratory.
For additional information regarding the research opportunities available at the Riley Heart Research Center for Cardiology Fellows, please contact Dr. Mark Payne.
Undergraduate Summer Internship